Bioinformatics

The cores listed below are located at Harvard Medical School, affiliated institutions, or other Harvard Schools. 

Drosophila RNAi Screening Center

The mission of the DRSC is to provide the community with RNAi reagent libraries and a screening platform for high-throughput screens in Drosophila cultured and primary cells. Also included at the DRSC is the Transgenic RNAi Project (TRiP). The mission of the TRiP is to generate validated in vivo fly stocks for tissue-specific gene knockdown in whole animals. We provide access to information, protocols, data and software tools via our DRSC and TRiP website and underlying FlyRNAi database. The DRSC also provides access to state-of-the-art instrumentation for high-throughput, high-content fluorescence confocal imaging.

Core Director - Stephanie Mohr
Core Website - http://fgr.hms.harvard.edu/

HMS imaging cores website: https://microscopy.hms.harvard.edu

Harvard Chan Bioinformatics Core

In an effort to provide bioinformatics analysis services and training to the HMS Community, the HMS Tools and Technology Program has provided additional support and resources to the HSPH Bioinformatics Core (HBC). HBC provides expertise in areas such as array analysis, next-gen sequencing (NGS) and functional analysis. Their NGS support includes epigenetics, transcriptomics and re-sequencing studies. HBC works together with research computing groups on all aspects of data management.

Core Director - Shannan Ho-Sui
Core Website - http://bioinformatics.hms.harvard.edu/

Image and Data Analysis Core

IDAC provides image data analysis services to individual labs and core facilities at Harvard Medical School, including the ICCB-Longwood Screening Facility (ICCB-L), the Drosophila RNAi Screening Center (DRSC), and the Nikon Imaging Center (NIC).

Core Website - http://idac.hms.harvard.edu/
Contact the Core - http://idac.hms.harvard.edu/access_idac

 

Image Management Core at HMS

The Harvard Medical School Image Management Core is a new service of HMS Research IT Solutions to help researchers manage image data and metadata. The IMC was created in response to the growing complexity and difficulty of managing research image data. The first major offering of the IMC will be a shared installation of the OMERO image management platform. The HMS IT department will install and maintain an OMERO server for use by on-quad HMS researchers. This effort builds upon the successful use of the OMERO platform by the HMS LINCS project. Initial funding for this comes from the Tools and Technology Committee, HMS IT, and the Harvard Program in Therapeutic Science (HiTS).

Core Director- Jay Copeland
Core Website - http://imc.hms.harvard.edu/

SBGrid Advanced Research Computing (ARC) and Software Consortium

SBGrid ARC provides research computing support to ~20 structural biology laboratories in the Boston area. The SBGrid Consortium provides structural biologists around the world with a tested and refined software infrastructure that includes a large library of scientific applications to support research using X-ray crystallography, NMR, and electron microscopy. Members also benefit from access to SBGrid-supported high performance computing (HPC) resources and training opportunities.

Core Director - Jason Key
Operations Director - Michelle Ottaviano
ARC Website - https://sbgrid.org/corewiki/Home

Consortium Website - https://www.sbgrid.org/

 

Quantitative Biomedical Research Center (qBRC) at SPH