Additional Technologies

The HMS Bio-molecular NMR Facility provides access to small and large molecule solution state NMR spectroscopy in support of chemical and structural biology. The facility, unique in the Boston area, houses state-of-the-art 400, 500, 600, and 700MHz systems capable of conducting cutting edge multi-nuclear experiments in support of medicinal chemistry, fragment-based drug discovery, mechanistic studies of ligand binding to macromolecules, metabolomics, protein structure and dynamics, and research on NMR methodology related to translational research. A hybrid model of operation is employed where training is provided to enable investigators to run their own experiments, but staff assistance is available for project-based work that requires highly specialized skills. The facility serves both HMS investigators and those from each of the affiliates.

Core Director - Greg Heffron
Core Website - https://eqnmr.med.harvard.edu/

The Immunology Department’s Flow Cytometry core facility provides cutting edge instruments and expert advice for flow cytometry to all researchers across HMS and beyond. With three sorters, four analyzers, and availability at late hours, we can offer our services for a wide variety of cytometry applications. Capabilities include a Cytek Aurora spectral analyzer (up to 40 parameters), or high speed 6 way cell sorting on the 6-laser MoFlo Astrios. 

Core Directors - Chad Araneo
Core Website - https://immunology.hms.harvard.edu/resources/flow-cytometry

Note that the HMS Microfluidics Core Facility closed in June 2025.

The HMS Microfluidics Core Facility aims to provide space and the equipment to design, fabricate and conduct experiments with micro-fluidic devices to the research community of Harvard University and affiliated institutions. Additionally, provide training, fabrication, technical and scientific assistance to users in order to ensure success in their projects.

Former Core Director - Calixto Saenz
Admin Contact - Samantha Jalbert
Core Website - https://hms.harvard.edu/departments/microfluidicsmicrofabrication

The Research Computing (RC) Core is a set of billable services provided by Research Computing and HMS IT. The goal of the RC Core is to promote deeper collaboration across the greater Harvard biomedical research ecosystem. This includes improved capabilities and performance by establishing more transparent and sustainable IT services for our research community.

Research Computing will be providing the following billable services via the RC Core:

• High Performance Computing:
  • The O2 Cluster, which accommodates diverse requirements and workflows for HMS-affiliated researchers.
• Storage Options:
  • Active – intended for storing research data that is frequently accessed, modified, or computed against which includes Compute and Collaborations storage solutions.
  • Standby - is leveraged for infrequently accessed data that is still directly available for reference, retrieval, or analysis.

Core Director - Neil Coplan
Core Website - https://it.hms.harvard.edu/rc/core
Email - rccore@hms.harvard.edu

Preparing images for inclusion in scientific communication has long been a time-consuming, confusing and often frustrating endeavor. Research Imaging Solutions works to identify ways to streamline image preparation so researchers can maximize their time at the bench, writing grants and developing discoveries.

Research Imaging Solutions services are available to all Harvard, HMS, HSDM, HSPH and affiliated hospital employees. Expertise can be accessed in a way that acknowledges each kind of learning style: one-on-one consulting; workshop and seminars and online easy-to-follow guides and recipes. The accessibility and convenience of this Quad-centered service is supplemented by substantial web-based assistance at it.med.harvard.edu/ris, making Research Imaging Solutions a 24/7 resource.

Training
RIS skills training is based on the unique ways that researchers use proprietary scientific applications, Microsoft Office and a variety graphics programs to create, acquire and edit images that are included in grant applications, journal articles and presentations to the scientific community. Half-day workshops are free and address the specific imaging and presentation needs of researchers. Lunchtime Seminars are presented at no charge and cover topics including poster making, proper PowerPoint techniques and Photoshop tricks. Customized small group and one-on-one training is also available by contacting Research Imaging Solutions.

Core Director - Beth Beighlie
Core Website - https://it.hms.harvard.edu/our-services/research-computing/services/research-imaging-solutions/ris-seminar-handouts

The Research Instrumentation Core Facility enables the development of new scientific instruments in order to further research at Harvard Medical School and affiliated institutions. The facility provides consultations on the design of hardware or software, purchasing decisions, and assistance with implementation.  The staff will work with researchers to develop and fabricate customized electronic, optical, and mechanical devices, as well as software interfaces for these devices. Furthermore, the facility provides tools and workshop space for authorized researchers to design and prototype their own instruments.  The facility is staffed by a full-time Neurobiology device engineer and a staff engineer.

Core Director - Ofer Mazor
Core Website - http://instrumentation.hms.harvard.edu/

The Systems Biology FACS facility houses two state-of-the-art BD analyzers with high-throughput capability, a high-speed BD cell sorter with an automatic plate deposition unit, a Stratedigm analyzer with high-throughput capability, and both Mac and PC workstations for data analysis. Sorting services are offered through the facility, as well as instrument and software training. Instruments include a BD FACSCalibur (488nm/635nm; 4-color), BD SORP LSRII with HTS (405nm/488nm/594nm; 12-color), A Stratedigm S100EX with plate reader and liquid dispensing capabilities (405nm, 488nm, 561nm, and 640nm; 13 color), and a BD FACSAria IIu (405nm/488nm/633nm; 9-color). Data analysis software available at the facility includes ModFit, FlowJo, Diva 6.1.3, and CellQuestPro.

Interim Core Director - Samantha Jalbert
Core Website - http://flowcytometry.sysbio.med.harvard.edu/