Center for Macromolecular Interactions
The BCMP Center for Macromolecular Interactions (CMI) is a resource for the characterization of macromolecules and their interactions. The CMI provides training, scientific consultation, and access to shared biophysical equipment, including surface plasmon resonance (SPR), biolayer interferometry (BLI), isothermal titration calorimetry ITC), differential scanning fluorimetry (DSF), circular dichroism (CD), and multi-angle light scattering (SEC-MALS).
Bio-molecular NMR Facility
The HMS Bio-molecular NMR Facility supports NMR spectroscopy for biomedical research. The Bio-NMR Lab houses state-of-the-art 400, 500, 600, and 700MHz NMR systems capable of conducting multi-dimensional experiments in support of research on structure elucidation of natural products, medicinal chemistry, fragment-based drug discovery, metabolomics, and protein structure and dynamics. Training is provided to enable investigators to run their own experiments in a highly automated, user- friendly environment.
Immunology Flow Cytometry Facility
The Immunology Department’s Flow Cytometry core facility provides cutting edge instruments and expert advice for flow cytometry to all researchers across HMS and beyond. With three sorters, three analyzers, and availability at late hours, we can offer our services for a wide variety of cytometry applications. Most recent instrumentation include a new BD FACSymphony A5 (up to 28 parameters), or high speed 6 way cell sorting on the 6-laser MoFlo Astrios.
Core Director - Jeffery Nelson
Core Website - https://immunology.hms.harvard.edu/resources/flow-cytometry
Microfluidics Core at HMS
The HMS Microfluidics Facility aims to make the tools of microfabrication and microfluidics available to all HMS users. Microfluidics has the potential to do for biology what microprocessors have done for computational sciences by integrating complex chemical and biological processes into one chip, facilitating the study of complex biological systems.
Core Director - Calixto Saenz
Admin Contact - Barb Grant
Core Website - https://hms.harvard.edu/departments/microfluidicsmicrofabrication
Research Imaging Solutions for Scientific Communication
Preparing images for inclusion in scientific communication has long been a time-consuming, confusing and often frustrating endeavor. Research Imaging Solutions works to identify ways to streamline image preparation so researchers can maximize their time at the bench, writing grants and developing discoveries.
Research Imaging Solutions services are available to all Harvard, HMS, HSDM, HSPH and affiliated hospital employees. Expertise can be accessed in a way that acknowledges each kind of learning style: one-on-one consulting; workshop and seminars and online easy-to-follow guides and recipes. The accessibility and convenience of this Quad-centered service is supplemented by substantial web-based assistance at it.med.harvard.edu/ris, making Research Imaging Solutions a 24/7 resource.
RIS skills training is based on the unique ways that researchers use proprietary scientific applications, Microsoft Office and a variety graphics programs to create, acquire and edit images that are included in grant applications, journal articles and presentations to the scientific community. Half-day workshops are free and address the specific imaging and presentation needs of researchers. Lunchtime Seminars are presented at no charge and cover topics including poster making, proper PowerPoint techniques and Photoshop tricks. Customized small group and one-on-one training is also available by contacting Research Imaging Solutions.
Core Director - Beth Beighlie
Core Website - https://hms.harvard.edu/departments/hms-information-technology/research-imaging
Research Instrumentation Core Facility
The Research Instrumentation Core Facility enables the development of new scientific instruments in order to further research at Harvard Medical School and affiliated institutions. The facility provides consultations on the design of hardware or software, purchasing decisions, and assistance with implementation. The staff will work with researchers to develop and fabricate customized electronic, optical, and mechanical devices, as well as software interfaces for these devices. Furthermore, the facility provides tools and workshop space for authorized researchers to design and prototype their own instruments. The facility is staffed by a full-time Neurobiology device engineer and a staff engineer.
Systems Biology FACS Facility
The Systems Biology FACS facility houses two state-of-the-art BD analyzers with high-throughput capability, a high-speed BD cell sorter with an automatic plate deposition unit, a Stratedigm analyzer with high-throughput capability, and both Mac and PC workstations for data analysis. Sorting services are offered through the facility, as well as instrument and software training. Instruments include a BD FACSCalibur (488nm/635nm; 4-color), BD SORP LSRII with HTS (405nm/488nm/594nm; 12-color), A Stratedigm S100EX with plate reader and liquid dispensing capabilities (405nm, 488nm, 561nm, and 640nm; 13 color), and a BD FACSAria IIu (405nm/488nm/633nm; 9-color). Data analysis software available at the facility includes ModFit, FlowJo, Diva 6.1.3, and CellQuestPro.