Research Core Facilities provide access to highly specialized services, equipment, and staff that would otherwise be too expensive for an individual laboratory to support. 

Below is an expandable list of the HMS Quad Department Core Facilities and contact information. While most Cores are publicly available, some are required by their sponsors to limit access and to differentiate pricing. Policies regarding services, access, fees and prioritization vary by core and by institution. Please contact each core facility directly for more information.

List of Core Facilities

Analytical Chemistry Core

In the Analytical Chemistry Core at HMS there is an Agilent 6530 QTOF LCMS and an Agilent 6130 Single Quad LCMS available for use by investigators who can operate them independently, running their own samples and interpreting the results.

Core Director - Matt Henke
Core Website -

Array Tomography Core

Array tomography is a newly developed imaging technique that offers multiplex, ultra-high resolution volumetric imaging with depth-independent immunofluorescent staining. 

Core Director - Michelle Ocana
Core Contact - Mahmoud El-Rifai
Website -

Biopolymer Next/Gen Sequencing Facility

Core Instruments and AB 3730xl - Sanger DNA Sequencing and Fragment Analysis;Life Technologies Quant Studio7 - QPCR Assays;Agilent Bioanalyzer & TapeStation - DNA and RNA Quality Assessment; Hamilton StarPlus Robot - Automation Services; Illumina HiSeq2500, NextSeq 500 & MiSeq - Next-gen Sequencing and Wafergen Apollo 324 Library Construction Services; Fluidigm C1 Single Cell Autoprep - Single Cell Analysis; Luminex LS200 - XMap Assays; QiaCube - Sample Preparation (DNA and RNA); and an Oligonucleotide Ordering Program; Reagents and Supplies Stock Room Program. A Comprehensive web based Laboratory Information Management System (LIMS), provides facility users with access to order services, supplies, retrieve data, review invoices and make payments online.

Core Director - Robert Steen
Core Website -

Center for Macromolecular Interactions

The BCMP Center for Macromolecular Interactions (CMI) is a resource for the characterization of macromolecules and their interactions. The CMI provides training, scientific consultation, and access to shared biophysical equipment, including surface plasmon resonance (SPR), biolayer interferometry (BLI), isothermal titration calorimetry ITC), differential scanning fluorimetry (DSF), circular dichroism (CD), and multi-angle light scattering (SEC-MALS). 

Core Director - Kelly Arnett
Core Website -

Cell Biology Microscopy Facility

This core provides access to advanced light microscopes for the Harvard Medical School research community, including a lattice light sheet microscope. 

Core Director - Jennifer Waters
Core Manager - Talley Lambert
Core Website -

HMS imaging cores website:

Conventional Electron Microscopy Facility

The Harvard Medical School EM Facility is a fee-for-service core facility open to researchers in the HMS Quadrangle and the Longwood Medical area. The Facility provides services and supervision in Transmission Electron Microscopy.

Core Director - Maria Ericsson
Core Website -

Cryo-EM Center

The Harvard Cryo-Electron Microscopy Center for Structural Biology is a joint effort of Harvard Medical School, Dana-Farber Cancer Institute, Boston Children’s Hospital, and Massachusetts General Hospital to provide state-of-the-art cryo-EM instrumentation and expertise for the Harvard structural biology community.  This user facility will offer consultation and training by staff in specimen preparation, microscope operation, image acquisition, and data analysis.  New vitrification devices are available for use and we are gradually bringing new users online for the Talos Arctica and Titan Krios microscopes as they become available.

Core Contact - Sarah Sterling
Core Website -


DF/HCC DNA Resource Core

The DF/HCC DNA Resource Core was established in the spring of 1999 to meet a growing need for DNA sequencing services at a cost that is affordable for academic labs. The services that we offer to users within the Dana Farber Harvard Cancer Center and the broader scientific community include DNA sequencing for large- and small-scale projects and plasmid distribution. Our highest priorities are quality assurance, user support and timely request fulfillment.

Core Director - Stephanie Mohr
Operations Director - Li Chan
Core Website -

DF/HCC Rodent Histopathology Core

The Rodent Histopathology Core is a Dana Farber/Harvard Cancer Center facility that is based at HMS. Services that the Core provides focus mainly on mouse histopathology, and include necropsy, phenotyping of organs and tissues, dissection and tissue processing, and one-on-one consultation. The facility also generates unstained paraffin and frozen sections to be used for immunohistochemistry. The core provides individual and group training sessions for postdoctoral fellows and graduate students on the development, phenotyping and characterization of animal models of cancers.

Core Faculty Director - Peter Howley
Core Manager - Li Zhang
Core Administrator - Lauri Wyner
Core Website -

Drosophila RNAi Screening Center

The mission of the DRSC is to provide the community with RNAi reagent libraries and a screening platform for high-throughput screens in Drosophila cultured and primary cells. Also included at the DRSC is the Transgenic RNAi Project (TRiP). The mission of the TRiP is to generate validated in vivo fly stocks for tissue-specific gene knockdown in whole animals. We provide access to information, protocols, data and software tools via our DRSC and TRiP website and underlying FlyRNAi database. The DRSC also provides access to state-of-the-art instrumentation for high-throughput, high-content fluorescence confocal imaging.

Core Director - Stephanie Mohr
Core Website -

HMS imaging cores website:

East Quad NMR Facility

The East Quad NMR Faciltiy (EQNMR) is a core facility for Bio-molecular NMR spectroscopy. The EQNMR Lab houses state-of-the-art 400, 500, 600, and 700MHz NMR systems capable of conducting multi-dimensional experiments in support of research on structure elucidation of natural products, medicinal chemistry, fragment-based drug discovery, metabolomics, and protein structure and dynamics. Training is provided to enable investigators to run their own experiments in a highly automated, user- friendly environment.

Core Director - Greg Heffron
Core Website -

Harvard Chan Bioinformatics Core

In an effort to provide bioinformatics analysis services and training to the HMS Community, the HMS Tools and Technology Program has provided additional support and resources to the HSPH Bioinformatics Core (HBC). HBC provides expertise in areas such as array analysis, next-gen sequencing (NGS) and functional analysis. Their NGS support includes epigenetics, transcriptomics and re-sequencing studies. HBC works together with research computing groups on all aspects of data management.

Core Director - Shannan Ho-Sui
Core Website -

ICCB-Longwood Screening Facility

The ICCB-Longwood Screening Facility assists investigators in carrying out high-throughput screens of chemical and RNAi libraries to identify new tools for biological research. The ICCB-Longwood compound collection is continuously growing. Over 500,000 compounds are currently available for screening, including > 12,000 'known bioactive' compounds, many of which have been characterized in animal models or in the clinic. Multiple human and mouse whole-genome siRNA libraries, as well as miRNA mimic and inhibitor libraries, are available for RNAi screening. Laboratory automation equipment is also available for use by the community for non-screening projects. The facility employs a staff-assisted screening model.

Core Director - Caroline Shamu
Deputy Director - Jennifer Smith
Admin Contact -
Core Website -

HMS imaging cores website:

Image and Data Analysis Core

IDAC provides image data analysis services to individual labs and core facilities at Harvard Medical School, including the ICCB-Longwood Screening Facility (ICCB-L), the Drosophila RNAi Screening Center (DRSC), and the Nikon Imaging Center (NIC).

Core Website -
Contact the Core -


Image Management Core

The Harvard Medical School Image Management Core is a new service of HMS Research IT Solutions to help researchers manage image data and metadata. The IMC was created in response to the growing complexity and difficulty of managing research image data. The first major offering of the IMC will be a shared installation of the OMERO image management platform. The HMS IT department will install and maintain an OMERO server for use by on-quad HMS researchers. This effort builds upon the successful use of the OMERO platform by the HMS LINCS project. Initial funding for this comes from the Tools and Technology Committee, HMS IT, and the Harvard Program in Therapeutic Science (HiTS).

Core Director- Jay Copeland
Core Website -

Immune Imaging Core

The BL2+ Imaging Facility provides the infrastructure and expertise for In-Vivo imaging of host pathogen interactions in infected mice.

Core Director - Uli von Adrian
Core Website -

Immunology Flow Cytometry Facility

The Immunology Department’s Flow Cytometry core facility provides cutting edge instruments and expert advice for flow cytometry to all researchers across HMS and beyond. With three sorters, three analyzers, and availability at late hours, we can offer our services for a wide variety of cytometry applications. Most recent instrumentation include a new BD FACSymphony A5 (up to 28 parameters), or high speed 6 way cell sorting on the 6-laser MoFlo Astrios.

Core Director - Chad Araneo
Core Website -

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Microfluidics Core

The HMS Microfluidics Facility aims to make the tools of microfabrication and microfluidics available to all HMS users. Microfluidics has the potential to do for biology what microprocessors have done for computational sciences by integrating complex chemical and biological processes into one chip, facilitating the study of complex biological systems.

Core Director - Calixto Saenz
Admin Contact - Barb Grant
Core Website -

MicRoN: Microscopy Resources on the North Quad

The MicRoN (Microscopy Resources on the North Quad) offers dedicated expertise in imaging and experimental design in light microscopy as well as technical support and basic maintenance of our microscopes. It primarily serves Microbiology, Immunology and Genetics departments but it is open to other Quad Departments. Our core includes widefield, TIRF, single point scanning and spinning disk confocal, multiphoton and SIM-TIRF microscopes.


Core Director - Paula Montero-Llopis
Core Website -

HMS imaging cores website:

Mouse Behavior Core

The Mouse Behavior Core (MBC) is a fee-for-service core providing a 3,000 sq. ft. state-of-the-art mouse behavior research facility. It is jointly supported by Harvard Medical School and Brigham and Women's Hospital. This is a full service facility, providing training and guidance to investigators on best research practices, developing new tests, equipment and procedures. The staff promotes the highest standards of mouse behavior research.

Core Director - Barbara Caldarone
Admin Contact - Paul Lorello
Core Website -

Mouse Imaging Core

The HMS Mouse Imaging Core provides researchers with in-vivo mouse imaging capabilities for endpoint and longitudinal studies using either luminescent or fluorescent reporters in an animal biosafety level 2 environment. Staff from ICCB-Longwood oversee the IVIS (In-Vivo Imaging System) Lumina II mouse imager and its use, while the IVIS room is operated and maintained by HCCM (Harvard Center for Comparative Medicine). Staff members provide access to and training on the imager and data analysis computers, while HCCM oversees all room and animal operations including facility access, safety training and orientation, animal transfers and husbandry, and protocol approval.

Core Director - Jennifer Smith
Core Website -

Nascent Transcriptomics Core

The mission of the Nascent Transcriptomics Core (NTC) is to offer the community a resource for the analysis of nascent transcription, providing new insights into gene regulation and enabling highly-sensitive identification of regulatory regions such as enhancers.

We offer consultation on experimental design as well as library construction services for Start-seq, PRO-seq, and TT-seq. In addition, the NTC looks forward to expanding these offerings as we develop and optimize new nascent RNA sequencing methods in partnership with the HMS community.

Core Contact - Seth Goldman

Neurobiology Imaging Facility

The facility offers a wide-range of optical imaging equipment, technical and analytical support as well as full service imaging, tissue clearing, array tomography and In Situ. The imaging equipment includes whole slide scanning, live cell imaging, confocal, lightsheet and super-resolution (STORM & STED) as well as basic brightfield and widefield microscopes.

Core Directors - Michelle Ocana and Aurelien Begue
Core Website -
Services Website -

HMS imaging cores website:

Nikon Imaging Center at Harvard Medical School

The NIC is a core light microscopy facility developed in partnership with Nikon Instruments Inc. and Micro Video Instruments Inc. The NIC@HMS maintains a wide range of light microscopy stations, including laser scanning confocal, spinning disk confocal, TIRF, STORM super-resolution, FRAP/photoactivation and more. All users are trained to use the equipment; no prior imaging experience is necessary. The NIC@HMS also offers an extensive educational program, including hands-on workshops for theoretical and practical training on light microscopy techniques.

Core Director - Jennifer Waters
Core Website -

HMS imaging cores website:

Research Computing

Research Computing manages the O2 and Orchestra High Performance Compute Cluster environments, with over 12000 compute cores.  HPC enables researchers to scale up their analyses for maximum efficiency and productivity.  The RC team provides infrastructure support for research web and database applications. RC also boasts a consulting service, providing advice on the best use of resources, implementing analyses, and conducting user training in cluster usage, basic programming languages, and statistical analysis.

Senior Director for Research Computing - Bill Barnett
Research Data Manager - Jessica Pierce
Website -

Research Imaging Solutions for Scientific Communication


Preparing images for inclusion in scientific communication has long been a time-consuming, confusing and often frustrating endeavor. Research Imaging Solutions works to identify ways to streamline image preparation so researchers can maximize their time at the bench, writing grants and developing discoveries.

Research Imaging Solutions services are available to all Harvard, HMS, HSDM, HSPH and affiliated hospital employees. Expertise can be accessed in a way that acknowledges each kind of learning style: one-on-one consulting; workshop and seminars and online easy-to-follow guides and recipes. The accessibility and convenience of this Quad-centered service is supplemented by substantial web-based assistance at, making Research Imaging Solutions a 24/7 resource.

RIS skills training is based on the unique ways that researchers use proprietary scientific applications, Microsoft Office and a variety graphics programs to create, acquire and edit images that are included in grant applications, journal articles and presentations to the scientific community. Half-day workshops are free and address the specific imaging and presentation needs of researchers. Lunchtime Seminars are presented at no charge and cover topics including poster making, proper PowerPoint techniques and Photoshop tricks. Customized small group and one-on-one training is also available by contacting Research Imaging Solutions.

Core Director - Beth Beighlie
Core Website -

Research Instrumentation Core Facility

The Research Instrumentation Core Facility enables the development of new scientific instruments in order to further research at Harvard Medical School and affiliated institutions. The facility provides consultations on the design of hardware or software, purchasing decisions, and assistance with implementation.  The staff will work with researchers to develop and fabricate customized electronic, optical, and mechanical devices, as well as software interfaces for these devices. Furthermore, the facility provides tools and workshop space for authorized researchers to design and prototype their own instruments.  The facility is staffed by a full-time Neurobiology device engineer and a staff engineer.

Core Director - Ofer Mazor
Core Website -

SBGrid Computing Core and Software Consortium

SBGrid Core team provides research computing support to 20 structural biology laboratories in Boston area. The SBGrid Consortium provides structural biologists worldwide with access to the computing resources they need to discover the shapes of the molecules of life. The Consortium includes X-ray crystallography, NMR and electron microscopy laboratories worldwide. Members share the costs of SBGrid's support services and gain access to a large collection of scientific applications and extensive computing resources.

Core Director - Jason Key
Admin Contact - Michelle Ottaviano
Core Website -

Single Cell Core

This Core supports single cell sequencing and provides resources for sequencing the transcriptomes individual cells and provides scientific advising for optimal experimental design.  The Core is partnering with the Harvard Chan Bioinformatics Core to offer support from experimental design through to data analysis.

Core Director - Sarah Boswell
Core Website -

Systems Biology FACS Facility

The Systems Biology FACS facility houses two state-of-the-art BD analyzers with high-throughput capability, a high-speed BD cell sorter with an automatic plate deposition unit, a Stratedigm analyzer with high-throughput capability, and both Mac and PC workstations for data analysis. Sorting services are offered through the facility, as well as instrument and software training. Instruments include a BD FACSCalibur (488nm/635nm; 4-color), BD SORP LSRII with HTS (405nm/488nm/594nm; 12-color), A Stratedigm S100EX with plate reader and liquid dispensing capabilities (405nm, 488nm, 561nm, and 640nm; 13 color), and a BD FACSAria IIu (405nm/488nm/633nm; 9-color). Data analysis software available at the facility includes ModFit, FlowJo, Diva 6.1.3, and CellQuestPro.

Core Director - Jodene Moore
Core Website -

Systems Biology Microscopy Facility

(SBMF) is a core facility for light microscopy developed in partnership with Nikon Instruments Inc. and Micro Video Instruments Inc. The SBMF maintains laser scanning confocals, spinning disk confocals, a total internal fluorescence system, and other basic fluorescence and transmitted light microscopes. All users are offered training to use the equipment; no prior imaging experience is necessary.

Core Director - Jennifer Waters
Core Website -

HMS imaging cores website:

Taplin Biological Mass Spectrometry Facility

The Taplin Biological Mass Spectrometry facility provides mass spectrometry services to members of the HMS community as well as external users.

Core Director - Ross Tomaino
Core Website -

Thermo Fisher Center for Multiplexed Proteomics

The Thermo Fisher Center offers quantitative protein expression profiling. The Center uses high resolution mass spectrometer (Orbitrap Fusion™ Tribrid™ Mass Spectrometer) and isobaric tandem mass tags (TMT) to quantify protein or phosphopeptide expression from cells, tissues or immunoprecipitated protein samples. Currently the TMT technology allows for the analysis of 6 - 11 samples within a single experiment by sample multiplexing. This allows us to study several conditions in a single experiment. The services are provided to the HMS community as well as external users.

Core Director - Prof. Steven P. Gygi
Core Website -

Transgenic Mouse Core

The Transgenic Mouse Core has all of the equipment necessary for generation of transgenic mice including a Nikon Diaphot microscope equipped with Nomarski Optics and Narishige micromanipulators for microinjections, Nikon surgical microscopes for egg isolation ad transfer, a sutter needle puller and a de Fonbbrune microforge. The facility maintains mice necessary for egg donors, egg recipients, and vasectomized males. This is a non-profit facility and charges are based upon anticipated mouse costs, maintenance of mice and equipment, purchase of necessary surgical supplies and chemicals, and personnel costs. 

ES cell culture services have been offered for 15 years. Our staff carries out electroporation of targeting vectors into ES cells and provides investigators with DNA to identify ES cells carrying the desired recombination events. Staff then expand the appropriate ES cells for microinjection into blastocysts by the Transgenic Mouse Core. 

In recent years, the core has expanded its list of services to include CRISPR injections and cryopreservation. 


Core Director- Lina Du
Core Administrator - Lauri Wyner
Core Website - Division of Immunology (click on Resources)